Graduation Level Topics

1. Extraction of Neurotransmitters from Brain Tissue for Quantification

Graduation students can extract dopamine and serotonin from rodent brain tissue using homogenization and chromatography. Levels are analyzed using HPLC. This project introduces practical neurochemistry, and aligns with Indian neurobiology labs studying neurotransmitter imbalances in neurological disorders.

2. Basic Electrophysiology: Recording Neural Action Potentials

Students can set up extracellular recording electrodes to monitor neural activity from invertebrate nerve cords (e.g., earthworm). Action potentials are recorded and analyzed. This hands-on project introduces neurophysiology, widely practiced in teaching labs in India.

3. Immunohistochemistry for Detection of Neural Proteins

Graduation projects can involve staining brain sections with antibodies against neural markers such as GFAP or synaptophysin. Fluorescent microscopy is used for visualization. This project provides basic exposure to neuro-immunotechnology, commonly applied in Indian neuroscience centers.

4. Use of Cell Culture to Study Neurotoxic Effects of Chemicals

Students can culture neuroblastoma cells and expose them to pesticides or heavy metals. Cell viability is assessed using MTT assay. This project introduces neurotoxicology, important in India where environmental exposure to toxins affects neurological health.

5. Neuroinformatics: Building Brain Pathway Databases

Graduation students can compile and map neuro-signaling pathways using bioinformatics software. Databases are compared with existing resources like KEGG. This project introduces computational neuro-biology, relevant to Indian students in biotechnology courses.

6. EEG Recording for Brain Activity Monitoring

Students can perform EEG recordings on human volunteers during different cognitive tasks. Waveforms are analyzed for alpha, beta, and delta rhythms. This project provides practical exposure to neurodiagnostics, commonly used in Indian hospitals for epilepsy and sleep studies.

7. Neuropharmacology Study Using Invertebrate Models

Graduation students can test neurotransmitter agonists or antagonists on cockroach or snail nervous systems. Neural response is measured by simple electrophysiological tools. This project introduces students to pharmacological testing, which is foundational in Indian neuropharmacology research.

8. Isolation of Neurotrophic Factors from Serum Samples

Students can extract and quantify BDNF (Brain Derived Neurotrophic Factor) using ELISA from animal or human serum. Levels are compared across conditions. This project introduces molecular neurobiology, relevant to Indian psychiatric and neurological biomarker studies.

9. Behavioral Studies in Rodents for Learning and Memory

Graduation students can perform maze-based learning tests (T-maze or Morris water maze) on rats. Performance is measured as time to completion. This project reflects experimental neuroscience, applied in India to screen cognitive enhancers and neuroprotective agents.

10. Neurogenetics: PCR-based Analysis of SNPs Linked to Neurological Disorders

Students can perform PCR amplification of specific SNPs linked to disorders like Parkinson’s or Alzheimer’s using DNA samples. Gel electrophoresis or sequencing validates the polymorphisms. This project introduces neurogenetics, a field growing in Indian medical biotechnology.

11. Neuroanatomical Staining for Brain Tissue Visualization

Graduation students can apply Nissl or Golgi staining on rodent brain slices to visualize neuronal cell bodies and dendritic structures. Microscopic analysis helps identify different brain regions. This project introduces classical neuroanatomical techniques, still used in Indian neuroscience teaching labs.

12. Effect of Caffeine on Locomotor Activity in Rodents

Students can administer caffeine to rats or mice and measure locomotor activity using an open field test. Data is compared with control animals. This project links neuropharmacology with behavior, relevant in India where lifestyle neurobiology is gaining research interest.

13. Neurotoxicity Assessment Using Zebrafish Models

Graduation students can expose zebrafish embryos to pesticides and observe neural development defects under microscopy. Survival and morphology are quantified. This project reflects India’s use of zebrafish in low-cost neurotoxicology studies.

14. Neurotransmitter Quantification Using ELISA Kits

Students can use commercially available ELISA kits to measure neurotransmitters such as dopamine, GABA, or serotonin in blood or tissue samples. Concentrations are compared under different conditions. This project is practical for Indian neuro labs studying stress and psychiatric disorders.

15. Brain Slice Preparation for Electrophysiology Demonstration

Graduation students can prepare acute hippocampal slices from rodents and perform field potential recordings. Stimulation-response curves demonstrate synaptic physiology. This project introduces electrophysiology protocols widely applied in Indian neuroscience labs.

16. Neurobehavioral Impact of Herbal Extracts

Students can test extracts from Ayurvedic plants such as Bacopa monnieri (Brahmi) or Withania somnifera (Ashwagandha) on rodent learning and memory models. Cognitive performance is quantified using maze tests. This project reflects India’s integration of traditional medicine with modern neuroscience.

17. Immunoblotting for Neural Protein Analysis

Graduation projects can involve extracting proteins from brain tissue and performing Western blotting for markers such as synapsin or tau. Band intensity reflects protein expression. This project introduces students to neuro-molecular analysis, practiced in Indian neuro labs working on dementia.

18. Neural Cell Culture Models for Drug Screening

Students can culture SH-SY5Y or PC12 neural cells and treat them with candidate drugs. Cell survival, neurite outgrowth, and differentiation are quantified microscopically. This project mirrors early-stage drug testing, relevant in Indian pharmaceutical neuro research.

19. Study of Circadian Rhythm Using Locomotor Activity Monitoring

Graduation students can monitor rodent activity cycles under light-dark conditions to study circadian rhythms. Activity patterns are recorded using automated cages. This project introduces chronobiology, relevant to India’s emerging sleep and biological rhythm research.

20. Neurodevelopmental Studies in Chick Embryos

Students can expose chick embryos to neuroactive compounds during early incubation and examine neural tube formation. Morphological changes are recorded. This project introduces embryonic neurodevelopment models, commonly used in Indian developmental biology labs.

21. Effect of Alcohol on Cognitive Performance in Rodents

Graduation students can administer ethanol to rats and evaluate memory impairment using maze-based behavioral assays. Learning deficits are quantified compared to controls. This project introduces neuropharmacology and reflects India’s rising research on alcohol’s neurological impact.

22. Neurodegeneration Studies Using Oxidative Stress Models

Students can treat neuronal cell cultures with hydrogen peroxide to induce oxidative stress. Neuronal death is measured with viability assays. This project demonstrates neurodegenerative mechanisms, widely applied in Indian labs for Alzheimer’s and Parkinson’s disease models.

23. Detection of Myelin Proteins in Brain Tissue

Graduation projects can involve isolating rodent brain myelin and analyzing proteins such as MBP (Myelin Basic Protein) using SDS-PAGE and Western blotting. Results reveal myelination patterns. This project supports research on demyelinating diseases, relevant to Indian multiple sclerosis studies.

24. Electroencephalographic (EEG) Effects of Meditation

Students can record EEG patterns from volunteers before and after guided meditation. Alpha and theta wave changes are analyzed. This project connects neuroscience with traditional Indian practices like yoga and meditation, increasingly studied for mental health benefits.

25. Neurobehavioral Testing of Anxiety in Rodents

Graduation students can perform elevated plus maze or open field tests to assess anxiety-like behavior in rodents. Pharmacological or herbal treatments are evaluated for anxiolytic effects. This project reflects India’s focus on mental health and stress biology.

26. Neuroinflammation Analysis in Brain Tissue Sections

Students can stain rodent brain sections for microglial activation markers (e.g., Iba1). Imaging and quantification provide insights into neuroinflammatory responses. This project supports studies on neuroinflammation, highly relevant to Indian research on neurodegenerative diseases.

27. Study of Neural Reflexes in Amphibians

Graduation students can perform simple reflex arc experiments using frog spinal cord preparations. Latency and reflex strength are measured under different stimuli. This classical project introduces fundamental neurophysiology, still demonstrated in Indian teaching labs.

28. Neuroimaging Basics Using fNIRS (Functional Near-infrared Spectroscopy)

Students can use fNIRS to monitor cortical activation during simple cognitive tasks in humans. Hemodynamic responses are recorded non-invasively. This project introduces neuroimaging technologies, now entering Indian academic setups as affordable alternatives to fMRI.

29. Neurotransmitter Modulation by Stress Exposure in Rodents

Graduation students can expose rodents to acute stress (e.g., restraint) and measure neurotransmitter levels in the brain using biochemical assays. Data reflects stress-induced neurochemical changes. This project aligns with Indian neuroscience research on stress and depression.

30. Isolation and Culture of Primary Neurons from Rodent Embryos

Students can dissect embryonic rodent brains, isolate neurons, and culture them in vitro. Neuronal morphology and synaptic connectivity are observed under microscopy. This project introduces advanced neurocell culture techniques, practiced in Indian neuro labs.

31. Neurobehavioral Impact of Music on Cognitive Function

Graduation students can expose rodents or human volunteers to classical or rhythmic music and test memory using behavioral tasks. Changes in EEG or maze performance are recorded. This project integrates neuroscience with cultural practices, relevant in India’s music therapy research.

32. Role of Antioxidants in Protecting Neurons from Oxidative Stress

Students can treat neural cell cultures with antioxidants like vitamin E or plant extracts before oxidative insult. Cell survival and ROS levels are quantified. This project demonstrates neuroprotection, important for Indian research on neurodegenerative diseases.

33. Study of Spinal Cord Reflex Modulation by Drugs

Graduation projects can test reflex responses in frog or rat spinal cords before and after administration of drugs like lidocaine. Reflex strength and latency are compared. This project provides hands-on neurophysiology relevant for pharmacology courses in India.

34. Analysis of Brain Hemispheric Dominance Using Cognitive Tasks

Students can perform lateralization studies in humans by testing hand preference, reaction times, and simple Stroop tasks. Results reveal hemispheric processing differences. This project introduces cognitive neurobiology, increasingly applied in Indian psychology-neuroscience integrations.

35. Histological Analysis of Neurodegeneration

Graduation students can stain rodent brain sections with H&E or cresyl violet to detect neuronal loss after neurotoxin exposure. Microscopy confirms degenerative changes. This project is foundational in neuropathology, practiced in Indian labs working on Parkinson’s models.

36. Neurobehavioral Effects of Nicotine in Rodents

Students can administer nicotine and monitor locomotion, anxiety, and learning using behavioral assays. Results are compared with controls. This project reflects neuropharmacology relevant to India’s tobacco use and addiction biology research.

37. Detection of Apoptosis in Neural Cells Using Flow Cytometry

Graduation projects can involve treating neuronal cultures with toxins and staining with Annexin V/PI. Flow cytometry quantifies apoptotic populations. This project introduces advanced cell analysis, common in Indian biomedical research.

38. Cognitive Enhancement Studies Using Ayurvedic Formulations

Students can test Ayurvedic formulations like Brahmi-based tonics in rodent memory models. Maze performance and neurotransmitter levels are evaluated. This project highlights India’s heritage-based neuropharmacology, merging traditional medicine with biotechnology.

39. Electromyography (EMG) for Neuromuscular Function Testing

Graduation students can record EMG signals from human volunteers during muscle contraction. Signal amplitude and frequency are analyzed. This project introduces neurodiagnostics, routinely used in Indian hospitals for neuromuscular disorders.

40. Neural Basis of Stress Reduction via Yoga Breathing

Students can record heart rate variability (HRV) and EEG in volunteers before and after yoga-based breathing sessions. Data reveals relaxation-linked neurophysiological changes. This project reflects India’s strength in integrating traditional practices with neurobiology.

41. Role of Exercise in Enhancing Neuroplasticity

Graduation students can compare rodent groups exposed to treadmill running with sedentary controls. Hippocampal BDNF levels are measured using ELISA. This project connects lifestyle biology with neuroscience, relevant in India’s focus on exercise and brain health.

42. Neurobehavioral Impact of Air Pollution Exposure

Students can expose rodents to controlled particulate matter and monitor memory and anxiety using behavioral assays. Neuroinflammatory markers are measured in brain tissue. This project links environmental biotechnology with neurobiology, reflecting India’s air quality challenges.

43. Effect of Sleep Deprivation on Cognitive Function

Graduation students can subject rodents to sleep restriction and evaluate memory performance in maze tasks. Stress hormone levels are also measured. This project introduces sleep neuroscience, increasingly studied in Indian labs.

44. Study of Synaptic Plasticity in Simple Neural Models

Students can record long-term potentiation (LTP) in rodent hippocampal slices using electrophysiology setups. Amplitude changes in excitatory postsynaptic potentials are analyzed. This project provides hands-on exposure to mechanisms of learning and memory.

45. Effect of Omega-3 Fatty Acids on Brain Function

Graduation students can supplement rodent diets with omega-3 fatty acids and evaluate cognitive function through maze tests. Neurotransmitter levels are analyzed biochemically. This project reflects nutrition-neurobiology integration, important in India’s functional food research.

46. Neurobehavioral Study of Social Interaction in Rodents

Students can evaluate rodent social preference and interaction in controlled arenas. Results are used to model autism-like behaviors. This project introduces behavioral neuroscience, relevant to Indian studies on neurodevelopmental disorders.

47. Study of Neuroendocrine Regulation via Stress Hormones

Graduation students can measure cortisol or corticosterone levels in stressed animals using ELISA. Correlations with behavior are analyzed. This project connects endocrinology with neuroscience, widely practiced in Indian neuro labs.

48. Neuroprotective Role of Curcumin in Toxin-induced Models

Students can administer curcumin in rodent models of neurotoxicity and monitor behavioral and biochemical markers. Antioxidant enzyme levels are quantified. This project reflects India’s emphasis on turmeric-derived neuroprotection.

49. Non-invasive Brain Stimulation with tDCS Demonstrations

Graduation students can perform transcranial direct current stimulation (tDCS) on volunteers during simple cognitive tasks. Reaction time and accuracy are measured. This project introduces emerging neurotechnology being piloted in Indian research hospitals.

50. Neurocomputational Modeling of Neural Networks

Students can build simple computational models of neural circuits using software like MATLAB or NEURON. Simulations of action potential propagation and synaptic plasticity are studied. This project merges computational and experimental neuroscience, gaining importance in  institutes.

Post-Graduation Level Topics

1. CRISPR-Cas9 Mediated Gene Editing in Neural Stem Cells

Postgraduates can apply CRISPR-Cas9 to knock out or correct genes linked to neurological disorders such as Huntington’s or Parkinson’s disease. Neural stem cells are cultured, edited, and validated through sequencing. This project reflects advanced neurogenomics, now entering Indian research institutions.

2. Brain-Computer Interface (BCI) Development for Communication in Paralysis

Students can design EEG-based BCI systems to decode brain signals into commands for simple computer tasks. Signal processing and accuracy are evaluated. This project supports neuroprosthetic development, a field gaining attention in Indian neuroengineering labs.

3. Single-cell Transcriptomics of Neurons in Neurodegeneration Models

Postgraduates can isolate single neurons from rodent models of Alzheimer’s and perform RNA-seq. Differential expression of stress and survival genes is analyzed. This project introduces cutting-edge transcriptomics, now applied in Indian neurobiology centers.

4. Stem Cell Therapy for Spinal Cord Injury Models

Students can culture mesenchymal stem cells, differentiate them into neural lineages, and transplant them into rodent spinal cord injury models. Functional recovery is assessed through behavioral and histological studies. This project reflects regenerative neurobiotechnology, under active exploration in India.

5. Neuroproteomics for Biomarker Discovery in Alzheimer’s Disease

Postgraduates can use mass spectrometry to analyze cerebrospinal fluid or brain tissue proteins in Alzheimer’s models. Candidate biomarkers are validated with ELISA or Western blot. This project aligns with India’s biomedical efforts to identify early diagnostic biomarkers.

6. Application of Optogenetics in Neural Circuit Analysis

Students can genetically modify neurons to express light-sensitive ion channels and stimulate them with lasers. Resulting behavior or electrophysiology responses are studied. This project reflects advanced neurotechnology, now emerging in Indian neuroscience research.

7. Artificial Intelligence Models for Predicting Epileptic Seizures

Postgraduates can develop deep learning algorithms trained on EEG datasets to predict seizure onset. Model accuracy and clinical relevance are tested. This project reflects India’s push to integrate AI into neurology and diagnostics.

8. 3D Brain Organoids for Studying Neurodevelopmental Disorders

Students can culture induced pluripotent stem cells (iPSCs) into 3D brain organoids. Developmental defects under genetic or chemical stress are studied. This project mirrors global advances and is being introduced in Indian stem cell labs for brain disease modeling.

9. Development of Nanoparticle-based Neuro-drug Delivery Systems

Postgraduates can design polymeric or lipid nanoparticles loaded with neuroprotective drugs. Blood-brain barrier penetration is tested in vitro using cell culture models. This project reflects India’s nanomedicine research applied to brain therapeutics.

10. Functional MRI-based Connectivity Mapping in Neurological Disorders

Students can analyze resting-state fMRI data to map altered connectivity patterns in disorders like depression or Parkinson’s. Graph theory-based network analysis is performed. This project reflects India’s growing neuroimaging facilities for translational neuroscience.

11. Epigenetic Regulation in Neurodegenerative Disorders

Postgraduates can analyze DNA methylation and histone modifications in brain tissue from Parkinson’s or Alzheimer’s rodent models. Epigenetic marks are correlated with gene expression changes. This project reflects India’s expanding interest in epigenetics as a therapeutic target in neurobiology.

12. Neural Tissue Engineering Using Biomaterial Scaffolds

Students can fabricate biodegradable polymer scaffolds seeded with neural stem cells for repairing brain or spinal cord injury. Cell attachment and neurite outgrowth are studied. This project introduces neuroregeneration, now being explored in Indian biomaterials research.

13. In silico Drug Design for Neurodegenerative Enzymes

Postgraduates can use molecular docking to screen inhibitors for targets such as acetylcholinesterase or MAO-B. Top candidates are synthesized and tested in vitro. This project integrates computational biology with neuropharmacology, an emerging field in Indian drug discovery labs.

14. Development of Biosensors for Neurotransmitter Detection

Students can design electrochemical biosensors using immobilized enzymes or nanomaterials for detecting dopamine and serotonin. Sensitivity and selectivity are tested in biological samples. This project reflects India’s growing research on point-of-care diagnostics for neurological monitoring.

15. Neural Network Simulation for Understanding Brain Disorders

Postgraduates can build large-scale computational models of cortical circuits to study epilepsy or schizophrenia-like network activity. Simulation outputs are compared with EEG/fMRI data. This project reflects India’s entry into neuroinformatics and brain modeling research.

16. Microbiome-Brain Axis Studies in Neurobehavioral Disorders

Students can analyze gut microbiota composition in rodent models of anxiety or depression. Correlations with neurotransmitter levels and behavior are studied. This project reflects India’s rising research into the gut-brain axis and psychiatric disorders.

17. Exosome-mediated Neuroregeneration

Postgraduates can isolate exosomes from mesenchymal stem cells and test their neuroprotective effects in rodent stroke models. Neurotrophic factor content is analyzed using proteomics. This project introduces cutting-edge cell-free therapy, now under pilot research in India.

18. Neuroinformatics Platforms for Integrating Omics Data

Students can design bioinformatics pipelines integrating genomics, transcriptomics, and proteomics data from neurological disease studies. Patterns are analyzed for biomarker discovery. This project reflects India’s growing emphasis on big data in neuroscience.

19. Application of Magnetogenetics for Neural Modulation

Postgraduates can use magnetic nanoparticles linked to ion channels to control neuronal activity with external magnetic fields. Neural responses are recorded electrophysiologically. This futuristic project is gaining traction globally and entering Indian neurotech labs.

20. Gene Therapy Approaches for Lysosomal Storage Disorders Affecting the Brain

Students can use viral vectors to deliver corrective genes for disorders such as Tay-Sachs or Gaucher’s disease in neuronal cell cultures. Expression and lysosomal function are evaluated. This project introduces translational neuro-gene therapy, a field India is beginning to adopt.

21. High-throughput Screening of Neuroprotective Compounds

Postgraduates can use neuronal cell culture assays to screen herbal extracts and synthetic molecules for neuroprotection against oxidative stress. Hits are validated using viability and apoptosis markers. This project reflects India’s strong focus on drug discovery from Ayurveda and natural products.

22. Neuroimmunology: Role of Microglia in Neurodegeneration

Students can analyze microglial activation markers in rodent Alzheimer’s models using immunohistochemistry and flow cytometry. Inflammatory cytokine levels are quantified. This project highlights neuroinflammation, a major research area in Indian neuroscience labs.

23. 3D Bioprinting of Neural Tissues for Regenerative Studies

Postgraduates can use bioprinting technology with hydrogels and neural progenitor cells to fabricate neural tissue constructs. Structural integrity and cell viability are evaluated. This project reflects advanced neuroregeneration approaches emerging in India’s tissue engineering labs.

24. Neural Organoid Models for Autism Spectrum Disorders

Students can generate brain organoids from patient-derived iPSCs and analyze neurodevelopmental abnormalities. Transcriptomic profiling is performed to identify dysregulated pathways. This project supports India’s growing research in neurodevelopmental disorders.

25. Development of RNA Therapeutics for Neurodegenerative Diseases

Postgraduates can design siRNA or antisense oligonucleotides targeting misfolded proteins in Huntington’s or ALS models. Gene knockdown efficiency is measured using qPCR. This project introduces RNA-based therapies, now a frontier in Indian biotechnology research.

26. Machine Learning for Brain Imaging Data Analysis

Students can apply machine learning algorithms to MRI or EEG datasets for automated classification of epilepsy or dementia. Model accuracy is validated against clinical diagnosis. This project reflects India’s integration of AI into neurodiagnostics.

27. Nanoneurotechnology for Targeted Brain Stimulation

Postgraduates can develop magnetic nanoparticles that respond to external fields to modulate neural activity. Effects on synaptic plasticity are studied in vitro. This futuristic project is gaining global interest and Indian labs are beginning pilot studies.

28. Neurogenomics of Indian Population Variants

Students can analyze genetic polymorphisms in Indian cohorts associated with neurological disorders like Parkinson’s or schizophrenia. Population-specific SNP data is compared with global datasets. This project supports India’s genomic diversity research in neuroscience.

29. Optogenetic Dissection of Fear Circuits in Rodents

Postgraduates can selectively activate or inhibit amygdala neurons using channelrhodopsin-based optogenetics. Behavioral changes in fear conditioning paradigms are recorded. This project introduces advanced circuit-mapping tools now being piloted in Indian neuroscience institutes.

30. Development of Neuropharmacological Databases

Students can curate and digitize data on neuroactive compounds, mechanisms, and clinical outcomes into searchable databases. Integration with AI tools enables predictive drug discovery. This project is aligned with India’s digital initiatives in drug informatics.

31. Development of Blood-Brain Barrier (BBB) Models on a Chip

Postgraduates can design microfluidic BBB-on-chip systems using endothelial and astrocytic co-cultures. Permeability of neuro-drugs is tested. This project reflects cutting-edge neuropharmacology tools being adopted in Indian nanobiotech labs.

32. Neuroepigenomics in Stress and Depression Models

Students can study genome-wide methylation and histone modification patterns in rodent stress models. Bioinformatics pipelines are applied to identify altered genes. This project is highly relevant to India’s psychiatric research on stress-linked mental health issues.

33. Development of Neuroprosthetic Interfaces for Motor Recovery

Postgraduates can design electrode-based interfaces that decode motor cortex signals to control robotic limbs. Accuracy and adaptability are tested in animal models. This project supports India’s growing interest in neuroprosthetics for rehabilitation.

34. Application of CRISPR Interference (CRISPRi) in Neuronal Gene Regulation

Students can use CRISPRi to silence overexpressed genes in neuronal cell cultures linked to epilepsy or neurodevelopmental disorders. Knockdown efficiency is validated using qPCR. This project demonstrates advanced gene regulation techniques, now reaching Indian labs.

35. Use of iPSC-derived Dopaminergic Neurons for Parkinson’s Studies

Postgraduates can differentiate patient-derived iPSCs into dopaminergic neurons and study disease-specific phenotypes. Neuroprotective drugs are tested on these models. This project reflects India’s progress in stem cell-based personalized neuroscience.

36. Neurotoxicogenomics of Environmental Pollutants

Students can expose neural cultures to pesticides or heavy metals and analyze transcriptomic changes. Key neurotoxic pathways are identified. This project connects biotechnology with environmental health, relevant in India where pollutant exposure is widespread.

37. Neural Oscillation Analysis in Cognitive Disorders

Postgraduates can analyze EEG data to study abnormal neural oscillations in schizophrenia or ADHD. Computational models are used to interpret rhythmic disruptions. This project reflects advanced neurodiagnostic research, being developed in Indian psychiatry-neurobiology collaborations.

38. Exosome-based Liquid Biopsies for Neurological Disorders

Students can isolate exosomes from patient plasma and analyze miRNA or protein cargo as biomarkers for Alzheimer’s or Parkinson’s. Diagnostic sensitivity is compared with standard tests. This project is a frontier in Indian translational neuroscience.

39. Neuroinformatics-driven Virtual Brain Models

Postgraduates can integrate structural MRI, functional MRI, and connectome data to build virtual brain models. Simulations are used to predict disease progression in dementia. This project is aligned with global initiatives like Human Brain Project and Indian computational neuroscience growth.

40. Application of Neural Stem Cell-derived Exosomes in Stroke Recovery

Students can administer exosome preparations in rodent stroke models and monitor functional recovery through behavioral and histological studies. Proteomic content of exosomes is characterized. This project reflects cutting-edge regenerative neurotherapy under early Indian exploration.

41. Deep Learning for Automated Diagnosis of Brain Tumors

Postgraduates can train convolutional neural networks (CNNs) on MRI datasets to classify brain tumors. Accuracy is validated against clinical diagnosis. This project reflects India’s integration of AI into neuro-oncology diagnostics.

42. Neurogenetics of Epilepsy in Indian Populations

Students can sequence ion channel genes (e.g., SCN1A, GABRA1) in Indian patients with epilepsy. Variant frequencies are compared with global datasets. This project provides population-specific insights into neurogenetic disorders in India.

43. Development of Hybrid Neuro-electronic Interfaces

Postgraduates can fabricate electrode arrays integrated with nanomaterials to record and stimulate neural activity. Performance is tested in vitro on cultured neurons. This project reflects neuroengineering research expanding in India.

44. Application of Functional Connectivity Mapping in Meditation Studies

Students can use resting-state fMRI to analyze brain network connectivity in long-term meditation practitioners. Graph analysis highlights altered connectivity patterns. This project reflects India’s unique strength in combining traditional practices with neuroimaging.

45. Organoid Models for Neurotoxicology Screening

Postgraduates can expose brain organoids to pesticides or pharmaceuticals and analyze structural and transcriptomic changes. Data provides human-relevant neurotoxicity insights. This project is highly relevant in India where pesticide exposure impacts rural health.

46. Neurophotonics for Imaging Synaptic Plasticity

Students can apply two-photon microscopy to visualize synaptic activity in rodent hippocampal slices. Long-term potentiation (LTP) and structural remodeling are recorded. This project reflects India’s adoption of advanced imaging technologies in neuroscience.

47. Gene Therapy Using AAV Vectors for Parkinson’s Models

Postgraduates can package dopamine-synthesizing genes into adeno-associated viral vectors and deliver them into rodent striatum. Behavioral recovery and gene expression are evaluated. This project mirrors translational neurobiotech strategies emerging in Indian labs.

48. Neuroeconomics: Brain Activity in Decision-making

Students can use EEG or fMRI to study neural correlates of economic decision-making tasks in humans. Data analysis reveals reward and risk processing. This project introduces interdisciplinary neuroscience, slowly growing in Indian academic centers.

49. Multi-omics Integration in Alzheimer’s Research

Postgraduates can combine genomics, transcriptomics, proteomics, and metabolomics datasets from Alzheimer’s models. Bioinformatics integration identifies key dysregulated pathways. This project reflects India’s push toward systems biology in neuroscience.

50. Roadmap for Neurobiotechnology Startups in India

Students can prepare feasibility studies on neuro-diagnostics, neuro-drug delivery, or BCI devices. Market analysis, IP generation, and regulatory pathways are discussed. This project supports India’s startup ecosystem where neuro-biotech is an emerging field.